Lab Members

Paul R. Langlais

  • Associate Professor, Department of Medicine, Division of Endocrinology, University of Arizona College of Medicine
  • Director Quantitative Proteomics Laboratory, Center for Disparities in Diabetes, Obesity & Metabolism, Department of Medicine, Division of Endocrinology, University of Arizona College of Medicine
Principal Investigator

     I was born French Canadian, Montreal to be exact, in 1975. My family moved to San Antonio in '78, so I grew up in the good old Texas public school system while spending my summers as a kid back in Quebec (which I still do when I can). I graduated from Texas Tech University in 1997 and realized that I liked Cell Biology, so I got lucky and ended up as a Research Assistant in an insulin signalling lab that Fall, all of which led me to a PhD in biochemistry from the University of Texas Health Science Center at San Antonio. I met my boss, Larry Mandarino, when he interviewed me for grad school and we both left UTHSCSA for Arizona State University together in 2005, him as the Chair of Kinesiology (a department that went bye-bye), me as a Post-Doctoral Fellow. Spent too long there before taking an Assistant Professor position at the Mayo Clinic in Arizona in 2012. Realized pretty quickly that Mayo held no future for me, so we all ended up at the University of Arizona College of Medicine in the Fall of 2016, which turned out to be where we should have started in Arizona in the first place. Love the UA, so good to be back at a health science center and an institution that has a passion for basic biomedical research. 

     I started my career as a scientist in an era where radiation was the main approach to study protein phosphorylation (this was '97, the internet had just come out and I don't even know if I had an email address, I don't think so). Luckily for me, I met the right people and got an early introduction to mass spectrometry. As a result, my training incorporated basic molecular biology, traditional signaling techniques, microscopy, and eventually mass spectrometry and proteomics. During this scientific journey, I became self-proficient as an end user capable of running mass spectrometers to study proteins. This led to a lot of collaboration, so much so, that we developed numerous proteomics facilities, all of which cumulated to the creation of the University of Arizona College of Medicine Quantitative Proteomics Laboratory, a resource we have designed to offer UA investigators a chance to use quantitative proteomics to answer their own personal research questions.

     I am fortunate enough to have a very loving family, a power trio, with my wife Leah, and our daughter Sophia. I enjoy spending time with the girls and watching Sophia turn into a beautiful little maniac. I also get my kicks playing music, SH*TLOADS OF GOLF, listening to music, reading, fishing, snorkeling, exercising, being outdoors, watching movies, barbequing, eating cheeseburges and french fries and chocolate, drinking whatever is being offered to me, and laughing at my idiot friends while I too act like a 14-year old moron. I also like winning money from said friends, the holidays with my family, October, and decorating my house during Halloween in a way that scares little kids so much they end up too afraid to grab the candy and I get all the chocolate.


Saniya Barbour - 2024 - ????

Undergraduate Student - UROC-Minimizing Health Disparities (MHD) Program

Summer 2024 - I was conacted by Tianna Urrea MacMeans the Program Coordinator of the Undergraduate Research Opportunities Consortium (UROC) in late Spring of 2024 to see if I was available to mentor a student that was participating in the UROC-Minimizing Health Disparities (MHD) Program. This seemed like a no-brainer for me, I feel a sense of duty to support the UROC and UBRP efforts here at the UA if I am available. Seeing as Mac McGraw was going to be back in the lab running things for the summer, I knew we had a solid situation for immersing students in Langlais Lab Camp. Enter Saniya Barbour, straight from New York City! Saniya was an excellent fit from the get-go and BONUS she intends to pursue a PhD in biomedical research! Saniya's interests actually lie in Neuroscience although she's been doing a nice job taking on glucose uptake with us. Saniya handled the lab like a pro throughout the summer and enjoyed it so much because I mean come on who doesn't love the Langlais Lab, she ended up staying with us as part of her federal work study program. She's now on her second year with us here in the lab and she has been a taking on all the freggin' western blots for our work on microtubules in insulin action...the project that never dies. We've really benefited from having Saniya with us and I'm personally looking forward to see where she ends up after the Langlais Lab seeing as she's actively seeking out her best choices and opportunities for graduate school. 


Austin Lipinski - 2019-????

Research Specialist

Austin comes to us straight outta college! Austin is now the go-to person for the proteomics lab we run across the hall. Austin realized in his mid 20s that he should get a degree cause hard labor is hard. He realized he liked science so he got some kind of scientific double major and while doing that met Mack. Once Natalie and James had to move to North Carolina, the Langlais Lab was fortunate to get a lead on Austin through Mack who recommended Austin as a replacement for Natalie. Since showing up in the late Fall of 2019 Austin has had no choice but to get with the program. Let's just see if he can survive the science gauntlet, he's done pretty damn good so far. GOOD LUCK AUSTIN. 

UPDATE! Austin is awesome.


Mac McGraw - 2022 - ????

Was an Undergraduate Thesis Honors Student and is Now a Medical Student

Spring 2022 - Ah yes, Mac McGraw. In his spare time, when he's not volunteering to help feed the homeless, or running a Physiology Student Group, or participating in a Student Diabetes Club, or doing 512 things for the early entrance program (HEAP) for UA Medical School, he dabbles in a little bit of Langlais Lab. Mac comes to us from the Mandarino Lab, where he helped out on some of the Center for Disparities in Diabetes, Obesity & Metabolism BioBank biz. Seeking a more bench-centric lab for his Phyiology Honors Thesis, Dr. Mandarino recommended Mac consider an experience with us. Mac has been such a fantastic addition to the lab because he already has an in-depth understand of type 2 diabetes, being type 1 himself. I'm pretty sure Mac has taught me more than I have taught him. When I grow up, I want to be like Mac.  

 

UPDATE Fall 2023 - Mac graduated Spring 2023 from college with something like 239 awards. OF COURSE he went straight into medical school weeks later. Apparently, Mac will be spending his summer doing his medical school research project in the ol' Langlais Lab hell hole, or at least he says he is, until he bails on us for someone fancier. 

UPDATE Spring 2024 - Looks like Mac is going to follow through with his Medical Student Research Program project in the Langlais Lab, can't get rid of this dude.

UPDATE Fall 2024 - Man. Now it looks like we're going to have Mac for the rest of his medical school experience, he's decided to take on a "Research Distinction" track. That's right, in the good ol' Langlais Lab. Good. We need him.