• Slide 4

    Discovering new effects of insulin on microtubule dynamics

  • Slide 2

    G2L1, MARK2, CLIP2, EB1, AGAP3, and CKAP5 undergo insulin-regulated phosphorylation

  • Slide 3

    Insulin stimulates acetylation of alpha-tubulin at Lysine 40 and microtubule stabilization

  • Slide 1

    Discovery of the CLASP2 protein network in adipocytes

Home Page

     Welcome to the Paul R. Langlais Laboratory website, the end of the internet, cause if you’ve made it here, you just may have ran out of things to look for.

     The Langlais Lab is directed by Paul Robert Langlais PhD, an Associate Professor at the University of Arizona College of Medicine, Department of Medicine, Division of Endocrinology. Dr. Langlais is also an affiliate of the University of Arizona Health Sciences Center for Disparities in Diabetes, Obesity and Metabolism, the UA Physiological Sciences Graduate Interdisciplinary Program, and also serves as Director of the University of Arizona College of Medicine Quantitative Proteomics Laboratory.

     The research focus of the Langlais Lab is to discover and characterize the protein signaling mechanisms responsible for controlling insulin-stimulated glucose uptake. We are currently obsessed with our discovery that insulin affects an entire network of microtubule-associated proteins, which we hypothesize are the main coordinators of insulin-stimulated microtubule dynamics. For more on that mixed business, head on over to our research page, where we may be able to answer a few Qs while attempting to keep it short and sweet.